|What are the possible side effects of
Serious side effects are not likely to occur. Stop using tretinoin
topical and seek emergency medical attention if you experience an
allergic reaction (shortness of breath; closing of your throat; swelling
of your lips, face, or tongue; or hives).
You may experience some burning, warmth, stinging, tingling, itching,
redness, swelling, dryness, peeling, or irritation while you are using
tretinoin topical. If these side effects are excessive, talk to your
doctor. You may need a lower dose or less frequent applications of
If you notice a change in your skin color, contact your doctor.
Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially
What other drugs will affect tretinoin topical?
Do not use tretinoin topical without first talking to your doctor if you
are taking any of the following medicines: a thiazide diuretic such as
hydrochlorothiazide (HCTZ, HydroDiuril, Esidrix, Microzide, Oretic),
chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone),
indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others; a
tetracycline antibiotic such as tetracycline (Sumycin, Panmycin,
Robitet, others), minocycline (Dynacin, Minocin, Vectrin), doxycycline
(Doryx, Monodox, Vibramycin, Vibra-Tabs), demeclocycline (Declomycin),
and others; a fluoroquinolone antibiotic such as lomefloxacin
(Maxaquin), sparfloxacin (Zagam), ciprofloxacin (Cipro), ofloxacin
(Floxin), and others; a sulfonamide antibiotic such as sulfamethoxazole
(Gantanol), sulfisoxazole (Gantrisin), sulfamethoxazole-trimethoprim
(Bactrim, Septra, Cotrim), and others; or a phenothiazine such as
chlorpromazine (Thorazine), prochlorperazine (Compazine), fluphenazine
(Permitil, Prolixin), promethazine (Phenergan, Promethegan),
perphenazine (Trilafon), and others.
The medications listed above may increase the sensitivity of your skin
to UV rays from sunlight or artificial light (e.g., sunlamps).
Generally, tretinoin topical should not be used with any of the
medicines listed above.
Do not use products containing benzoyl peroxide, sulfur, resorcinol, or
salicylic acid during treatment with tretinoin topical unless otherwise
directed by your doctor. The combination could lead to severe skin
Avoid as much as possible products that can increase skin irritation
such as other skin medicines (unless prescribed by your doctor);
medicated or abrasive (rough) soaps or skin cleansers; permanent wave
solutions; chemical hair removers or waxes; electrolysis; products with
alcohol, spices, astringents, or lime; cleansers, shampoos, or cosmetics
with a strong drying effect; or other products that may irritate your
Drugs other than those listed here may also interact with tretinoin
topical. Talk to your doctor and pharmacist before taking any
prescription or over-the-counter medicines.