What are the possible side effects of Glucophage?
• Stop taking Glucophage and seek emergency medical
attention if you experience an allergic reaction (difficulty breathing;
closing of your throat; swelling of your lips, tongue, or face; or hives).
• A small number of people who have taken Glucophage
have developed a serious condition called lactic acidosis that has been
fatal in up to 50% of cases. Lactic acidosis has occurred most often in
people whose kidneys were not working properly. Liver problems may also
increase the risk of developing lactic acidosis. Stop taking Glucophage
and call your doctor immediately if you experience a feeling of general
discomfort or sickness; weakness; sore or aching muscles; trouble
breathing, unusual drowsiness, dizziness or lightheadedness; unusual or
unexplained stomach upset (after the initial stomach upset that may occur
at the start of therapy with Glucophage); or the sudden development of a
slow or irregular heartbeat. These may be signs of lactic acidosis.
• Other, less serious side effects may be more likely to
occur. Continue to take Glucophage and talk to your doctor if you
· nausea, vomiting, abdominal pain, or diarrhea at the start of therapy;
· abdominal bloating or increased gas production; or
· decreased appetite or changes in taste (metallic taste in your mouth).
• Side effects other than those listed here may also
occur. Talk to your doctor about any side effect that seems unusual or
that is especially bothersome.
What other drugs will affect Glucophage?
• Before taking this medication, tell your doctor if you
are taking any of the following medications:
· a diuretic (water pill) such as furosemide (Lasix), bumetanide (Bumex),
ethacrynic acid (Edecrin), torsemide (Demadex), amiloride (Midamor),
triamterene (Dyazide, Maxzide, Dyrenium), spironolactone (Aldactone),
hydrochlorothiazide (HydroDiuril), chlorothiazide (Diuril), chlorthalidone
(Hygroton), indapamide (Lozol), metolazone (Zaroxolyn, Mykrox), and
· a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine
(Compazine), promethazine (Phenergan), and others
· an estrogen (Premarin, Prempro, Ogen, and others) or birth control pill
(Ovral, Lo-Ovral, Ortho-Novum, Triphasil, Levlen, Tri-Levlen, Alesse, and
· a calcium channel blocker such as nifedipine (Adalat, Procardia),
verapamil (Calan, Verelan, Isoptin), diltiazem (Cardizem, Dilacor XR),
felodipine (Plendil), bepridil (Vascor), amlodipine (Norvasc), and others;
· a steroid medication such as prednisone (Deltasone), methylprednisolone
(Medrol), dexamethasone (Decadron), and others;
· a thyroid medication (Synthroid, Levoxyl, Levothroid, and others),
· digoxin (Lanoxin, Lanoxicaps);
· procainamide (Pronestyl);
· quinidine (Cardioquin, others);
· cimetidine (Tagamet, Tagamet HB) or ranitidine (Zantac, Zantac 75);
· morphine (Astramorph, MS Contin, Roxanol, and others);
· trimethoprim (Proloprim, Trimpex, Septra, Bactrim);
· phenytoin (Dilantin);
· isoniazid (Nydrazid); or
· nicotinic acid or niacin (Nicobid, Nicolar, others).
• You may not be able to take Glucophage, or you may require a dosage
adjustment or special monitoring if you are taking any of the medicines
• Drugs other than those listed here may also interact
with Glucophage or affect your condition. Talk to your doctor and
pharmacist before taking any prescription or over-the-counter medicines.