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Flexeril is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.
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What are the possible side effects of cyclobenzaprine?

If you experience any of the following serious side effects, stop taking cyclobenzaprine and seek emergency medical attention:

An allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); seizures, hallucinations, or confusion; blurred vision; increased heart rate; or depression.

Other, less serious side effects may be more likely to occur. Continue to take cyclobenzaprine and talk to your doctor if you experience drowsiness or dizziness; dry mouth or a bad taste in your mouth; insomnia; difficulty urinating; or sweating.

If you stop taking this medication suddenly, you may experience some withdrawal effects.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect cyclobenzaprine?

Do not take cyclobenzaprine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Many drugs can increase drowsiness associated with cyclobenzaprine: antihistamines such as brompheniramine (Dimetane, Bromfed, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others; narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others); sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal); phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine); or antidepressants such as doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate).

Do not take any of the drugs listed above without the approval of your doctor.

The stomach medicine cimetidine (Tagamet, Tagamet HB) and pain relievers such as aspirin, ibuprofen (Motrin, Advil), indomethacin (Indocin), ketoprofen (Orudis, Orudis KT, Oruvail), fenoprofen (Nalfon), flurbiprofen (Ansaid), naproxen (Aleve, Anaprox, Naprosyn), and nabumetone (Relafen) may all increase the pain-relieving effects of cyclobenzaprine. Use these drugs under the supervision of your doctor.

Drugs other than those listed here may also interact with cyclobenzaprine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.


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