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Celecoxib (Celebrex) is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Celecoxib works by reducing substances that cause inflammation, pain, and fever in the body....
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What are the possible side effects of celecoxib?

If you experience any of the following serious side effects, stop taking celecoxib and seek medical treatment or call your doctor immediately:

An allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); abdominal pain, tenderness, or discomfort; bloody, black, or tarry stools; nausea or heartburn; bloody vomit; unexplained weight gain; swelling or water retention; unusual fatigue or lethargy; a skin rash or itching; yellowing of your skin or eyes; "flu-like" symptoms; or unusual bruising or bleeding.

Other, less serious side effects may be more likely to occur. Continue to take celecoxib and talk to your doctor if you experience flatulence or diarrhea; dizziness; headache; or insomnia.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect celecoxib?

Before taking celecoxib, tell your doctor if you are taking any of the following drugs: Aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate-magnesium salicylate (Trilisate, Tricosal, others), and magnesium salicylate (Doan's, Bayer Select Backache Formula, others); an over-the-counter cough, cold, allergy, or pain medicine that contains aspirin, ibuprofen, naproxen, or ketoprofen; a diuretic (water pill) such as furosemide (Lasix), hydrochlorothiazide (HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Hygroton, Thalitone), and others; an angiotensin-converting-enzyme inhibitor (ACE inhibitor) such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), and others; a steroid medicine such as prednisone (Deltasone and others), methylprednisolone (Medrol and others), prednisolone (Prelone, Pediapred, and others), and others; an anticoagulant (blood thinner) such as warfarin (Coumadin); lithium (Eskalith, Lithobid, others); or fluconazole (Diflucan).

You may not be able to take an celecoxib, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with celecoxib. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

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